[Objective] Nano-sized nickel has received increasing attention as a novel material with tempting perspective in some application areas, such as catalysis, magnetic recording media, and fuel battery. The present production processes of nano-sized nickel face some limitations, such as smaller production scale and higher price of nano-sized nickel. Therefore, this work is aimed at developing a continuous production process of nano-sized nickel with low-cost and high-quality. [Methods] The amplification experiments of preparing nano-sized nickel by liquid-phase chemical reduction method through both batch process and continuous process respectively were carried out. The catalytic activity of nano-sized nickel was tested in the catalytic hydrogenation of p-nitrophenol to p-aminophenol. The nano-sized nickel particles prepared in the continuous production apparatus based on ceramic membrane filtration were characterized by XRD, FESEM and Mastersizer 2000. [Results] Experimental results show, for the batch preparation process, the catalytic activity of nano-sized nickel decreases obviously with an increase of the amplified factor, and decreases remarkably with prolonging the reducer gross feed time at certain amounts of reducer solution; for the continuous preparation processes, the catalytic activities of nano-sized nickel prepared in tubular reactor and kettle-tubular reactor are both quite close to that of the small-scale test, and the catalytic activity of nano-sized nickel prepared in semi-continuous kettle reactor is much lower than that of the small-scale test. Furthermore, a continuous production apparatus for preparing nano-sized nickel based on ceramic membrane filtration was set up. The mean particle size of as-prepared nano-sized nickel is about 60 nm. Compared with Raney nickel, the catalytic activity of as-prepared nano-sized nickel is much higher at similar reaction conditions, which may be due to the high-density surface defects of nano-sized nickel. [Conclusions] This work would be helpful for raising the production capacity of nano-sized nickel, and provide some references for preparing other nano-sized powders.