Title |
Study on synthesis and property of superparamagnetic contrast agent based on ferrite and dextran |
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Author |
Z.L. LIU1,* S.J. SUN1,*, D.Y. HU2, K.L. YAO1, Z. LI2, X.M. HU2 |
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Institute
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1. Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, P.R.China
2. Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, P.R.China |
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Keywords: |
ultrafine superparamagnetic iron oxide; oxidation; contrast agent; MR imaging |
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| Abstract | In this study we describe a novel method to prepare ultrafine superparamagnetic iron oxide (USPIO) colloid formed under alkaline conditions by oxidating ferrous iron-polysaccharide matrix with nitrate. The synthesized colloid was characterized by physicochemical means such as transmission electron microscopy (TEM), Fourier transformed infrared (FTIR), vibrating sample magnetometry (VSM). The results show that the diameter of the complex nanoparticles is decreased by accurately controlling the quantity of dextran added. The TEM indicates that the particles are spherical in shape and the nanoparticles are found to be less than 5 nm with narrow size distribution. The FTIR spectra indicate that the iron oxide is located by polymeric matrix. The magnetic measurement reveals the saturation magnetization values between 35-45 electromagnetic units per gram. We compared USPIO with SPIO agents in animal experiments. The in vivo MR results show that the synthesized USPIO colloid can achieve more sensitive images and could be used as a promising magnetic resonance imaging (MRI) contrast agent. |
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