Pluronic is a block copolymer based of polyethylene oxide and polypropylene, which has been used extensively in a variety of pharmaceutical formulations dues to its low toxicity, sustained release and tends to create micelle. Recently, attentions are paid to the Pluronic P105 micelle that has the characteristic of ultrasonic triggered release. This review describes the main finding and characteristics of this ultrasonic triggered release system, the evaluation method, influence factors, mechanism of ultrasonic triggered release as well as antitumor effect in vitro and in vivo have been discussed. The main limitations and its potential development of this system were discussed. Under the guidance of this ultrasonic triggered release mechanism, a novel fluoride anion-modified gelatin nanogel system for ultrasound-triggered drug release has been developed by the authors,, which can efficiently release the carried drug in response to ultrasound. Further animal evaluations are in progress.