Title |
Study on Target-orientation Anticancer Adriamycin-loaded Microspheres |
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Author |
Benlan LIN 1, Xiaodong SHEN1,* , Sheng CUI 1, Ruihua SHI2, Tingsheng LIN 2 |
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Institute
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1. College of Material Science and Technology of Nanjing University of technology, 210009, P.R.China 2. Department of Gastroenterology of the First Afiliated Hospital of NJMU, 210029, P.R.China |
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Keywords: |
adriamycin; target-orientation anticancer drug; Fe3O4 nanoparticles; effective drug loading; HPLC |
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| Abstract | prepared target-orientation anticancer adriamycin-loaded microspheres which were magnetic. [Methods] To prepare magnetic adriamycin-loaded microspheres by heating emulsion for solidification with adriamycin, HAS (Human serum albumin) and Fe3O4 nanoparticle as materials, got enwrapping degree by HRTEM and adriamycin content by HPLC. [Results] Crystal Fe3O4 nanoparticles were enwrapped by unformed adriamycin and HAS, the efficiency loading amount and the apparent loading amount of adriamycin-loaded microspheres with magnetic nanoparticles were 2.35% and 3.55%. [Conclusions] The method of heating emulsion for solidification could be used for preparing adriamycin-loaded microspheres. |
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